Mycologia
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DOI: 10.3852/mycologia.98.2.180
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Mycologia, 98(2), 2006, pp. 180-185.
© 2006 by The Mycological Society of America

A bioactive (1->3)-, (1->4)-ß-D-glucan from Collybia dryophila and other mushrooms


Maribel Pacheco-Sanchez

     Centre de recherche en horticulture, Pavillon de l’Envirotron, Université Laval, Québec QC, G1K 7P4 Canada, and Institut des nutraceutiques et des aliments fonctionnels, Université Laval, Québec QC, G1K 7P4 Canada

Yvan Boutin

     Institut des nutraceutiques et des aliments fonctionnels, Université Laval, Québec QC, G1K 7P4 Canada, Transbiotech, Cégep Lévis-Lauzon, 205 route Mgr Bourget, Lévis QC, G6V 6Z9 Canada

Paul Angers

     Institut des nutraceutiques et des aliments fonctionnels, Université Laval, Québec QC, G1K 7P4 Canada

André Gosselin
Russell J. Tweddell 1

     Centre de recherche en horticulture, Pavillon de l’Envirotron, Université Laval, Québec QC, G1K 7P4 Canada, and Institut des nutraceutiques et des aliments fonctionnels, Université Laval, Québec QC, G1K 7P4 Canada

Polysaccharides from higher Basidiomycete mushrooms, mainly ß-D-glucans, are considered to be potent bioactive fungal compounds. In this study a ß-glucan (1.237 x 106 Da) consisting of (1-> 3) and (1-> 4) glucosidic linkages, named Collybia dryophila polysaccharide (CDP), was extracted from the wild mushroom C. dryophila. CDP was shown to strongly inhibit nitric oxide production in activated macrophages suggesting that this polysaccharide displays a potential anti-inflammatory activity. In addition it was shown that polysaccharides similar to CDP (CDP-like) are present in Lentinus edodes and different wild mushrooms collected in northeastern North America.

Key words: anti-inflammatory activity, higher Basidiomycetes, Lentinus edodes, Marasmius oreades, polysaccharides

1 Corresponding author. E-mail: russell.tweddell{at}crh.ulaval.ca






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Copyright © 2006 by The Mycological Society of America.