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Penicillium dravuni, a new marine-derived species from an alga in Fiji

     Wyeth Research, Natural Products Microbiology, 401 North Middletown Road, Pearl River, New York 10965

Tim S. Bugni
Chris M. Ireland

     Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112

Penicillium dravuni is a new monoverticillate, sclerotium-forming species that was isolated from the alga Dictyosphaeria versluyii collected in Dravuni, Fiji. This species morphologically is similar to P. turbatum in the P. turbatum subseries of the P. thomii series of the Monoverticillata. The nuclear ribosomal internal transcribed spacer region exhibited 97% sequence similarity to known Penicillium spp. in the GenBank database. Phylogenetic analyses revealed that P. dravuni is related most closely to Eupenicillium brefeldianum, E. levitum, E. reticulosporum, E. javanicum, E. ehrlichii and P. simplicissimum. However this new species shares only a distant ancestor with this clade because it branches by itself early in the lineage. P. dravuni also is known to produce the secondary metabolites dictyosphaeric acids A and B and carviolin.

Key words: Dictyosphaeria, dictyosphaeric acids, carviolin, ITS, marine-derived, Trichocomaceae