Mycologia
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bok, J.-W.
Right arrow Articles by Griffiths, A. J. F.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Bok, J.-W.
Right arrow Articles by Griffiths, A. J. F.
Agricola
Right arrow Articles by Bok, J.-W.
Right arrow Articles by Griffiths, A. J. F.
Mycologia, 95(3), 2003, pp. 500-505.
© 2003 by The Mycological Society of America

Ultrastructural changes in Neurospora cells undergoing senescence induced by kalilo plasmids


Jin-Woo Bok
Ken-Ichiro Ishida
Anthony J. F. Griffiths 1

     Department of Botany, University of British Columbia, 6270 University Blvd., Vancouver, V6T 1Z4 Canada

In N. crassa and N. intermedia, the kalilo plasmid triggers senescence by insertion into mitochondrial DNA. To investigate the cell death pathway induced by this plasmid, juvenile and senescent subcultures of several senescent strains were examined by light and transmission electron microscopy, and at the DNA level. There were no signs of apoptotic events, such as shrinkage of the cytoplasm away from the cell wall, apoptotic bodies, internucleosomal DNA fragmentation or condensation of the cytoplasm while retaining mitochondria and endomembrane structure. Instead, swollen mitochondria lacking cristae and containing amorphous inclusions, and disruption of nuclear and mitochondrial membranes indicated a necrotic mode of cell death.

Key words: apoptosis, kalilo, mitochondria, necrosis, Neurospora, plasmid, senescence






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 by The Mycological Society of America.